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Facile and Green Chemistry Access to 5‐aryl‐1,2,4‐Triazolidine‐3‐thiones in Aqueous Medium
Author(s) -
Ramesh Rathinam,
Lalitha Appaswami
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600348
Subject(s) - yield (engineering) , chemistry , aryl , aqueous medium , condensation , solvent , aqueous solution , ethanol , organic chemistry , green chemistry , combinatorial chemistry , reaction mechanism , materials science , catalysis , alkyl , metallurgy , thermodynamics , physics
A clean, cost‐effective and very practical approach has been disclosed for the one‐pot, cyclo condensation of aromatic aldehydes with different thiosemicarbazides in aqueous ethanol leading to pharmaceutically diverse 5‐aryl‐1,2,4‐triazolidine‐3‐thiones in good yields under neutral reaction conditions. Simple operational procedure, high product yield, rapid and use of green solvent system make this protocol economical as well as environmentally benevolent.