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Synthesis of 2,5‐Hexanedione from Biomass Resources Using a Highly Efficient Biphasic System
Author(s) -
Li Yueqin,
Lv Guangqiang,
Wang Yuqi,
Deng Tiansheng,
Wang Yingxiong,
Hou Xianglin,
Yang Yongxing
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600280
Subject(s) - biomass (ecology) , chemistry , hydrolysis , methyl isobutyl ketone , aqueous two phase system , aqueous solution , catalysis , yield (engineering) , organic chemistry , phase (matter) , ketone , materials science , oceanography , metallurgy , geology
2,5‐hexanedione, a valuable platform chemical which is being broadly used in biofuel, medicinal chemistry and drug discovery, was synthesized from biomass derived dimethyl furane using a highly efficient biphasic system. In this biphasic systems, mineral acids (HCl, H 2 SO 4 and H 3 PO 4 ) dissolved in aqueous phase were used as hydrolysis catalysts. The hydrolysis reaction is suggested to take place at the interface between the aqueous and the organic phase. But more importantly, water‐immiscible organic phase could continuously extract the in‐situ produced 2,5‐hexanedione from the interface to prevent the extended contact between the 2,5‐hexanedione and the acids, thereby avoiding the oligomerization side reactions A yield of 99 % could be obtained when methyl isobutyl ketone (MIBK) was the organic phase in the biphasic system.