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Transition‐Metal‐Free Thiolation Annulation of 2‐Fluorophenylacetylene Derivatives: Expedient Synthesis of Benzo[ b ]thiophenes Using Na 2 S•9H 2 O
Author(s) -
Li Yibiao,
Cheng Liang,
Li Bin,
Jiang Shaohua,
Chen Lu,
Shao Yan
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600270
Subject(s) - annulation , thiophene , transition metal , chemistry , metal , stereochemistry , combinatorial chemistry , organic chemistry , catalysis
We present here valuable extensions to our previous work in preparing highly functionalized benzo[b]thiophene via thiolation annulation of 2‐fluorophenylacetylene derivatives using Na 2 S•9H 2 O under transition‐metal‐free conditions. This practical process was initiated by a Na 2 S•9H 2 O induced providing 2‐alkynyl benzenethiol, followed by annulation process affording the corresponding benzo[b]thiophene in moderate to good yields from simple and readily available starting materials.