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Sodium Cyanate Mediated Synthesis of Sulfonylurea and Sulfonyltriuret from Sulfonyl Chloride and Amine
Author(s) -
Hadianawala Murtuza,
Shaik Althaf,
Hasija Nisha,
Vasu Anuji K.,
Datta Dr Bhaskar
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600259
Subject(s) - sulfonylurea , sulfonyl , chemistry , cyanate , amine gas treating , combinatorial chemistry , chloride , reactivity (psychology) , sodium , nucleophile , organic chemistry , catalysis , medicine , alkyl , endocrinology , alternative medicine , pathology , insulin
Synthetic methods providing access to sulfonylureas are immensely valuable considering the wide usage of sulfonylurea derivatives as hypoglycemic drugs and herbicides. In this work, the scope of a sodium cyanate mediated single‐step synthesis of sulfonylureas from amines and sulfonyl chlorides as starting materials has been examined. Success of the single‐step reaction in affording desired aliphatic and aromatic sulfonylurea products depends on the combination of suitable nucleophilicity of amines and reactivity of sulfonyl chlorides. In addition to providing access to sulfonylureas, the interplay of reactivities of the amine and sulfonyl chloride is found to result in emergence of specific oligomeric products that are characterized as novel sulfonyltriurets. In effect, the sodium cyanate mediated single‐step reaction for synthesis of sulfonylureas also provides a method for synthesis of specific sulfonyltriurets. Electronic effects accompanying the amine and sulfonyl chloride modulate the nature of major product between sulfonylureas and sulfonyltriurets. The sodium cyanate mediated single‐step reaction is thus sought to be considered as a method for synthesis of sulfonyltriurets in addition to sulfonylureas.