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Multifunctional, Biocompatible, Non‐peptidic Hydrogels: from Water Purification to Drug Delivery
Author(s) -
Baker Benjamin C.,
Higgins Clare L.,
Ravishankar Divyashree,
Colquhoun Howard M.,
Stevens Gary C.,
Greco Francesca,
Greenland Barnaby W.,
Hayes Wayne
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600249
Subject(s) - drug delivery , biocompatible material , self healing hydrogels , chemistry , drug , combinatorial chemistry , drug carrier , portable water purification , organic chemistry , pharmacology , biomedical engineering , medicine
Abstract A novel series of low molecular weight non‐peptidic, biocompatible super‐hydrogelators with both water purification and drug delivery properties have been developed. Linking the bis aromatic urea groups responsible for gelation together to form bi‐ and tri‐armed gelators, affords good control over gelation and water purification properties. The use of the gels as effective drug scavengers and delivery systems has been demonstrated with dye substrates, via pH inversion, as monitored by UV‐vis spectroscopy. Finally, the systems′ abilities as both drug scavenging and delivery systems have been demonstrated with the clinically‐approved drugs chlorpromazine and doxorubicin, respectively.