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Cover Picture: Single molecule fluorescence reveals dimerization of myristoylated Src N‐terminal region on supported lipid bilayers (ChemistrySelect 4/2016)
Author(s) -
Le Roux AnabelLise,
Castro Bruno,
Garbacik Erik T.,
Garcia Parajo Maria F.,
Pons Miquel
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600218
Subject(s) - myristoylation , molecule , proto oncogene tyrosine protein kinase src , fluorescence , monomer , membrane , dock , chemistry , biophysics , crystallography , cover (algebra) , materials science , phosphorylation , biochemistry , biology , physics , polymer , mechanical engineering , organic chemistry , engineering , quantum mechanics
The cover picture shows an artist's representation of the N‐terminal region of the c‐Src oncogene product anchored to the surface of the cell membrane by its myristoylated SH4 group and the intrinsically disordered unique domain. Single molecule fluorescence photo bleaching was used to demonstrate that a fraction of c‐Src molecules spontaneously form dimers only when they are anchored to the membrane surface. Switching from monomers to dimers is suggested to be a new mechanism for the efficient location of specific sites on the membrane surface from which c‐Src signaling takes place. More information can be found in the Communication by Pons et al. (DOI: 10.1002/slct.201600117).