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Enantiospecific Formal Synthesis of Inthomycin C
Author(s) -
Athawale Paresh R.,
Kashinath K.,
Reddy D. Srinivasa
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600128
Subject(s) - formal synthesis , enantiomer , stereochemistry , natural product , chemistry , combinatorial chemistry
An enantiospecific synthesis of Hatakeyama's intermediate enynol has been accomplished in both enantiomeric forms. As these intermediates can be converted to (3 R )‐inthomycin C and (3 S )‐inthomycin C through respective enynol intermediates using reported procedures, present effort may be regarded as formal synthesis of inthomycin C in both enantiomeric forms. Our synthesis highlights the use of pantolactone chiral pool and thus reconfirms the previously assigned absolute stereochemistry as 3R to the natural product inthomycin C.