Tandem Arylation/Friedel‐Crafts Reaction of  O ‐Hydroxy Bisbenzylic Alcohols with Diaryliodonium Salts: One Pot Synthesis of Unsymmetrical 9‐Arylxanthenes | Zendy

Mao Song | Zendy; Hua Zerui | Zendy; Wu Xunshen | Zendy; Yang Yang | Zendy; Han Jianwei | Zendy; Wang Limin | Zendy

Premium

Tandem Arylation/Friedel‐Crafts Reaction of O ‐Hydroxy Bisbenzylic Alcohols with Diaryliodonium Salts: One Pot Synthesis of Unsymmetrical 9‐Arylxanthenes

Author(s) -

Mao Song,

Hua Zerui,

Wu Xunshen,

Yang Yang,

Han Jianwei,

Wang Limin

Publication year - 2016

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201600036

Subject(s) - tandem , yield (engineering) , friedel–crafts reaction , chemistry , brønsted–lowry acid–base theory , base (topology) , catalysis , organic chemistry , reaction conditions , combinatorial chemistry , materials science , mathematics , mathematical analysis , metallurgy , composite material

A one‐pot synthesis of 9‐arylxanthenes from easily prepared o ‐hydroxy bisbenzylic alcohols and diaryliodonium salts has been reported. O ‐hydroxy bisbenzylic alcohols were utilized to generate carbinols in situ with diaryliodonium salts promoted by base. Carbinols were then subjected to Brønsted acid catalyzed cyclization to furnish 9‐arylxanthenes. A variety of symmetrical and unsymmetrical 9‐aryxanthenes have been prepared assisted by base and Brønsted acid under mild conditions with satisfactory yields (up to 95 % yield). Furthermore, the procedure is capable of tolerating a wide range of substrates (36 examples).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research