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Verteporfin based silica nanoplatform for photodynamic therapy
Author(s) -
Gianotti E.,
Estevão B. Martins,
Miletto I.,
Tonello S.,
Renò F.,
Marchese L.
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600004
Subject(s) - verteporfin , photodynamic therapy , singlet oxygen , photosensitizer , materials science , chemistry , nanotechnology , photochemistry , oxygen , organic chemistry , retinal , biochemistry , choroidal neovascularization
A highly efficient nanoplatform for photodynamic therapy was obtained by covalent conjugation of verteporfin with mesoporous silica nanoparticles. Verteporfin has an intense absorption band in the red region of the Vis spectrum ensuring a deeper tissue penetration; this feature makes verteporfin‐based formulations particularly attractive for in vivo PDT applications. The verteporfin loading, dispersion and efficiency in the photoproduction and delivery of singlet oxygen ( 1 O 2 ) were carefully evaluated. In vitro tests have evidenced that the optimized nanoplatform is able to largely reduce HeLa cell proliferation after red‐light irradiation.