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A hidden Markov model for population‐level cervical cancer screening data
Author(s) -
Soper Braden C.,
Nygård Mari,
Abdulla Ghaleb,
Meng Rui,
Nygård Jan F.
Publication year - 2020
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.8681
Subject(s) - covariate , cancer registry , norwegian , medicine , cervical cancer , population , markov model , cancer , statistics , demography , markov chain , environmental health , mathematics , linguistics , philosophy , sociology
The Cancer Registry of Norway has been administrating a national cervical cancer screening program since 1992 by coordinating triennial cytology exam screenings for the female population between 25 and 69 years of age. Up to 80% of cancers are prevented through mass screening, but this comes at the expense of considerable screening activity and leads to overtreatment of clinically asymptomatic precancers. In this article, we present a continuous‐time, time‐inhomogeneous hidden Markov model which was developed to understand the screening process and cervical cancer carcinogenesis in detail. By leveraging 1.7 million individual's multivariate time‐series of medical exams performed over a 25‐year period, we simultaneously estimate all model parameters. We show that an age‐dependent model reflects the Norwegian screening program by comparing empirical survival curves from observed registry data and data simulated from the proposed model. The model can be generalized to include more detailed individual‐level covariates as well as new types of screening exams. By utilizing individual screening histories and covariate data, the proposed model shows potential for improving strategies for cancer screening programs by personalizing recommended screening intervals.