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Effects of covariance model assumptions on hypothesis tests for repeated measurements: analysis of ovarian hormone data and pituitary‐pteryomaxillary distance data
Author(s) -
Park Taesung,
Park JinKyung,
Davis Charles S.
Publication year - 2001
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.859
Subject(s) - multivariate statistics , covariance , multivariate analysis of variance , multivariate analysis , analysis of covariance , statistics , computer science , repeated measures design , focus (optics) , random effects model , linear model , econometrics , mathematics , medicine , physics , meta analysis , optics
In the analysis of repeated measurements, multivariate methods which account for the correlations among the observations from the same experimental unit are widely used. Two commonly‐used multivariate methods are the unstructured multivariate approach and the mixed model approach. The unstructured multivariate approach uses MANOVA types of models and does not require assumptions on the covariance structure. The mixed model approach uses multivariate linear models with random effects and requires covariance structure assumptions. In this paper, we describe the characteristics of tests based on these two methods of analysis and investigate the performance of these tests. We focus particularly on tests for group effects and parallelism of response profiles. Copyright © 2001 John Wiley & Sons, Ltd.