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Projecting the standard error of the Kaplan–Meier estimator
Author(s) -
Cantor Alan B.
Publication year - 2001
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.856
Subject(s) - standard error , estimator , statistics , kaplan–meier estimator , survival analysis , mathematics , econometrics
Clinical studies in which a major objective is to produce Kaplan–Meier estimates of survival probabilities should be designed to produce those estimates with a desired prespecified precision as measured by their standard errors. By considering the Peto and Greenwood formulae for the estimated standard error of the Kaplan–Meier estimate and replacing their constituents with expected values based on the study's design parameters, formulae for projected standard errors can be produced. These formulae are shown, through simulations, to be quite accurate. Copyright © 2001 John Wiley & Sons, Ltd.