Premium
Subgroup analysis with semiparametric models toward precision medicine
Author(s) -
Yuan Ao,
Chen Xiaofei,
Zhou Yizhao,
Tan Ming T.
Publication year - 2018
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.7638
Subject(s) - parametric statistics , semiparametric model , computer science , semiparametric regression , econometrics , nonparametric statistics , wald test , statistics , statistical hypothesis testing , medical statistics , machine learning , artificial intelligence , mathematics
In analyzing clinical trials, one important objective is to classify the patients into treatment‐favorable and nonfavorable subgroups. Existing parametric methods are not robust, and the commonly used classification rules ignore the fact that the implications of treatment‐favorable and nonfavorable subgroups can be different. To address these issues, we propose a semiparametric model, incorporating both our knowledge and uncertainty about the true model. The Wald statistics is used to test the existence of subgroups, while the Neyman‐Pearson rule to classify each subject. Asymptotic properties are derived, simulation studies are conducted to evaluate the performance of the method, and then method is used to analyze a real‐world trial data.