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Sample size tables for exact single‐stage phase II designs
Author(s) -
A'Hern R. P.
Publication year - 2001
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.721
Subject(s) - sample size determination , statistics , stage (stratigraphy) , computer science , mathematics , biology , paleontology
Tables for single‐phase II trials based on the exact binomial distribution are presented. These are preferable to those generated using Fleming's design, which are based on the normal approximation and can give rise to anomalous results. For example, if the upper success rate is accepted, the lower success rate, which the trial is designed to reject, may be included in the final confidence interval for the proportion being estimated. Copyright © 2001 John Wiley & Sons, Ltd.