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Designs for phase I trials in ordered groups
Author(s) -
Conaway Mark R.,
Wages Nolan A.
Publication year - 2016
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.7133
Subject(s) - maximum tolerated dose , clinical trial , toxicity , phase (matter) , medicine , mathematics , statistics , computer science , chemistry , organic chemistry
We propose a new design for dose finding for cytotoxic agents in two ordered groups of patients. By ordered groups, we mean that prior to the study there is clinical information that would indicate that for a given dose one group would be more susceptible to toxicities than patients in the other group. The designs are evaluated relative to two previously proposed designs for ordered groups over a range of scenarios generated randomly from a family of dose‐toxicity curves. Copyright © 2016 John Wiley & Sons, Ltd.