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Random recombination and evolution of drug resistance
Author(s) -
Kleinman Alan
Publication year - 2015
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.6429
Subject(s) - phenomenon , recombination , context (archaeology) , statistical physics , selection (genetic algorithm) , computer science , physics , artificial intelligence , genetics , quantum mechanics , biology , paleontology , gene
The effects of random recombination on the random mutation and natural selection phenomenon can be understood by considering the mathematical behavior of this phenomenon. This phenomenon operates in a mathematically predicable behavior, which when understood, explains the empirical observations of this phenomenon. The mathematical behavior of random recombination is derived using the principles given by probability theory. The derivation of the equations describing the random recombination phenomenon is done in the context of an empirical example. Copyright © 2015 John Wiley & Sons, Ltd.