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Handling the limit of detection by extrapolation
Author(s) -
Longford Nicholas T.
Publication year - 2012
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.5373
Subject(s) - extrapolation , censoring (clinical trials) , limit (mathematics) , computer science , statistics , detection limit , mathematics , econometrics , statistical physics , physics , mathematical analysis
A general method of estimation with a variable observed subject to a limit of detection is introduced. It is based on extrapolation of the estimates obtained by increasing the limit of detection. Theoretical arguments support the method in some special cases, and it is explored by simulations. Several examples are presented and adaptations for other kinds of censoring explored. Copyright © 2012 John Wiley & Sons, Ltd.