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Two‐stage designs for Phase 2 dose‐finding trials
Author(s) -
Ivanova Anastasia,
Xiao Changfu,
Tymofyeyev Yevgen
Publication year - 2012
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.5365
Subject(s) - stage (stratigraphy) , maximum tolerated dose , adaptive design , bayesian probability , computer science , statistics , mathematical optimization , mathematics , clinical trial , medicine , biology , paleontology
We propose a Bayesian adaptive two‐stage design for the efficient estimation of the maximum dose or the minimum effective dose in a dose‐finding trial. The new design allocates subjects in stage two according to the posterior distribution of the target dose location. Simulations show that the proposed two‐stage design is superior to equal allocation and to a two‐stage strategy where only one dose is left in the second stage. Copyright © 2012 John Wiley & Sons, Ltd.