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A personal view of some controversies in allocating treatment to patients in clinical trials
Author(s) -
Senn Stephen
Publication year - 1995
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780142406
Subject(s) - statistician , blinding , clinical trial , selection (genetic algorithm) , randomization , drug development , intensive care medicine , computer science , medicine , psychology , drug , artificial intelligence , psychiatry , pathology
A non‐exhaustive but nevertheless wide‐ranging if biased and personal view of various matters affecting the allocation of treatments to patients in controlled clinical trials will be undertaken from the standpoint of a statistician working in drug development. The following topics are considered: the use of ‘placebos’ in the run‐in phase; the use of crossover trials; selection of patients; various matters concerning centres; two extreme alternatives to randomization, and various matters linking blinding and allocation.