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Exact power computation for dose—response studies
Author(s) -
Tang ManLai,
Hirji Karim F.,
Vollset Stein E.
Publication year - 1995
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780142009
Subject(s) - computation , computer science , power analysis , sample size determination , power (physics) , polynomial , binary number , algorithm , mathematics , statistics , arithmetic , mathematical analysis , physics , quantum mechanics , cryptography
The toxicity of an agent or the therapeutic effect of a drug may be assessed by a dose‐response study. We present a method for computing the exact power of exact and large sample statistical tests employed for binary response data from such a study. This method, based on recursive polynomial multiplications, enables fast computation of exact power for studies with up to a moderately large sample size. We demonstrate the efficiency of our method using three examples. The method is suitable for the design and power analysis of dose—response studies in which the usual asymptotic approximations are suspect.