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Additivity test for composition of binomial effects in chromosome aberrations after radiation injury
Author(s) -
Komornik J.,
Mikulecky M.,
Beno M.
Publication year - 1995
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780141710
Subject(s) - additive function , outlier , chromosome , negative binomial distribution , toxicology , mathematics , medicine , statistics , biology , genetics , poisson distribution , mathematical analysis , gene
Additivity of clastogenic effects of two doses of radiation to human peripheral blood lymphocytes is considered. We compare the effects of combined tritium and gamma irradiation with the sum of the effects of either irradiation administered separately. Our solution is based on combination of de Moivre and Cramèr—Slucky theorems. The results for 14 subjects where the deletion types of chromosome aberrations were counted indicate a Normal distribution of the sample additivity index, oscillating non‐significantly around zero, with one outlier towards adaptivity and another towards synergism of the effect of the two doses absorbed by the cells.