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Marker values at the time of an AIDS diagnosis
Author(s) -
Taylor Jeremy M. G.,
Kim Dong Kee
Publication year - 1994
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780131915
Subject(s) - statistics , medicine , computer science , econometrics , mathematics
In this paper statistical methods are proposed to estimate the distribution of a CD4 T‐cell number at the time of a clinical AIDS endpoint from serial measurements of CD4 T‐cell values in a cohort study. The statistical formulation of the problem is that of survival analysis with interval censored data, but in which the endpoints are obtained with measurement error. A measurement error likelihood is developed, assuming normality of the CD4 distribution at AIDS. A maximum likelihood estimation procedure and a Gibbs sampling approach are implemented.