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Analysing survival in the presence of an auxiliary variable
Author(s) -
Finkelstein Dianne M.,
Schoenfeld David A.
Publication year - 1994
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780131706
Subject(s) - survival analysis , statistics , clinical trial , clinical endpoint , variable (mathematics) , econometrics , medicine , computer science , mathematics , mathematical analysis
A primary endpoint of AIDS trials is the length of survival. Often there is auxiliary information available on measures of disease progression, which significantly alter the risk of mortality. This paper explores the use of this information in obtaining a refined estimate of survival, and a test based on this estimate. The methods are applied to an AIDS clinical trial, and results of simulations are provided which compare the approach to standard methods for survival analysis.