Triangular test and randomized trials: Practical problems in a small cell lung cancer trial | Zendy

Pig JeanPierre | Zendy; Tarayre Michèle | Zendy; Auquier Ariane | Zendy; Arriagada Rodrigo | Zendy; le Chevalier Thierry | Zendy; Ruffié Pierre | Zendy; Rivière Alain | Zendy; Monnet Isabelle | Zendy; Chomy Pierre | Zendy; Tuchais Claude | Zendy

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Triangular test and randomized trials: Practical problems in a small cell lung cancer trial

Author(s) -

Pig JeanPierre,

Tarayre Michèle,

Auquier Ariane,

Arriagada Rodrigo,

le Chevalier Thierry,

Ruffié Pierre,

Rivière Alain,

Monnet Isabelle,

Chomy Pierre,

Tuchais Claude

Publication year - 1994

Publication title -

statistics in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.996

H-Index - 183

eISSN - 1097-0258

pISSN - 0277-6715

DOI - 10.1002/sim.4780131317

Subject(s) - randomized controlled trial , lung cancer , test (biology) , medicine , statistics , computer science , mathematics , oncology , biology , paleontology

The triangular test has been used to monitor survival data from a randomized trial in patients with small cell lung cancer. The results of consecutive interim analyses and the problems met by the data monitoring committee and the co‐ordinators are described. The methods as well as the consequences of the early stopping on the analysis and the results of this trial are discussed. From this experience, we believe that statistical stopping rules ‐ only one of the factors to be taken into account when deciding to stop a trial ‐ should be used with caution. Independent data monitoring committees may be useful in helping to review the ongoing results and advise the participants in the trial.

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