Premium
Assessing the significance of chromosome‐loss data: Where are suppressor genes for bladder cancer?
Author(s) -
Newton Michael A.,
Wu ShiQi,
Reznikoff Catherine A.
Publication year - 1994
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780130805
Subject(s) - suppressor , gene , chromosome , cancer , bladder cancer , genetics , biology , tumor suppressor gene , computational biology , oncology , medicine , carcinogenesis
Cytogenetic analysis reveals alterations of chromosome structure (losses, gains, and rearrangements of genetic material) in bladder cancer cells generated using an in oitrolin oioo transformation system. To predict possible locations of bladder cancer suppressor genes, we performed a robust Bayesian analysis of the chromosome‐loss data. We postulated a simple stochastic model to describe chromosome loss during tumour progression. Posterior computations are enabled by a dynamic simulation algorithm. Ordered by decreasing posterior probability of putatively harbouring a suppressor gene, we observe significant losses on chromosomes 3, 18, 13, 10, 11, and y .