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Inherent difficulties with active control equivalence studies
Author(s) -
Senn Stephen
Publication year - 1993
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780122412
Subject(s) - equivalence (formal languages) , competence (human resources) , computer science , null hypothesis , clinical trial , econometrics , psychology , mathematics , medicine , social psychology , discrete mathematics , pathology
A simple model is used to investigate the relevance of ‘competence’ to active control equivalence studies )ACES(. It is shown that to the extent that such trials are successful the results of such trials must raise doubts regarding their competence. ACES are thus more problematic than classical clinical trials and the problems with such studies cannot be solved simply by exchanging the usual roles of null and alternative hypotheses.