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An index of disease activity in rheumatoid arthritis
Author(s) -
Jones P. W.,
Ziade M. F. M.,
Davis M. J.,
Dawes P. T.
Publication year - 1993
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780121206
Subject(s) - rheumatoid arthritis , index (typography) , medicine , clinical disease , disease , statistics , mathematics , computer science , world wide web
This paper describes the Stoke Index which has been designed to give a global measure of disease activity in rheumatoid arthritis. The index is based on two objective laboratory measurements, one subjective and two semi‐objective clinical measurements, chosen from 13 measurements using clinical judgement. Variable selection routines in principal components analysis are used to demonstrate that the index measures clinically defined disease activity. Its sensitivity and reversibility are also considered. A comparison is carried out with another index (Mallya‐Mace) and a modification is suggested.