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Evaluation of multicentre clinical trial data using adaptations of the mosteller‐tukey procedure
Author(s) -
Ciminera Joseph L.,
Heyse Joseph F.,
Nguyen Ha H.,
Tukey John W.
Publication year - 1993
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780121105
Subject(s) - statistics , computer science , mathematics , medicine
Two procedures, based on proposals discussed by Mosteller and Tukey, are described for obtaining a combined estimate of the difference between two treatment means and its confidence interval from multicentre clinical trial data. Both procedures provide estimates in the possible presence of heteroscedasticity. The first procedure is designated the primary analysis for efficacy assessment. It omits treatment‐by‐centre interaction from the error term for treatment, unless there is substantial evidence of qualitative interaction (Ciminera et al. ) or other special circumstances. The second procedure is the primary analysis whenever there is substantial evidence of qualitative interaction, and can be used whenever there are other reasons to make an analysis allowing for interaction.