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The succession procedure for interim analysis: Extensions for early acceptance of h 0 and for flexible times of analysis
Author(s) -
Falissard Bruno,
Lellouch Joseph
Publication year - 1993
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780120107
Subject(s) - interim analysis , ecological succession , interim , computer science , statistics , mathematics , medicine , history , clinical trial , ecology , archaeology , biology
The succession procedure is a new method for group sequential analysis based on a succession of significant tests. In this paper, the procedure is extended by the addition of a lower boundary, which allows the early acceptance of the null hypothesis H 0 according to the stochastic curtailing approach. The succession procedure is also adapted to the type I error spending rate function α* (t) , leading to the method of semisequential analysis for which the times of analysis need not be specified in advance.