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Parametric versus non‐parametric methods for estimating cure rates based on censored survival data
Author(s) -
Cantor Alan B.,
Shuster Jonathan J.
Publication year - 1992
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780110710
Subject(s) - parametric statistics , statistics , survival analysis , cure rate , gompertz function , failure rate , parametric model , nonparametric statistics , mathematics , plateau (mathematics) , estimation , econometrics , computer science , medicine , surgery , mathematical analysis , management , economics
If a patient's failure time is incorrectly recorded as being too early, the correction will lower the plateau of the Kaplan‐Meier curve and, hence, the associated estimated cure rate. Implications of this counter‐intuitive observation are discussed. In addition, a parametric approach, based on the Gompertz distribution, to the problem of cure rate estimation is presented.