Premium
A general parametric approach to the meta‐analysis of randomized clinical trials
Author(s) -
Whitehead Anne,
Whitehead John
Publication year - 1991
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780101105
Subject(s) - randomized controlled trial , meta analysis , computer science , random effects model , parametric statistics , statistics , binary data , econometrics , mathematics , medicine , binary number , surgery , arithmetic
Abstract Meta‐analysis provides a systematic and quantitative approach to the summary of results from randomized studies. Whilst many authors have published actual meta‐analyses concerning specific therapeutic questions, less has been published about comprehensive methodology. This article presents a general parametric approach, which utilizes efficient score statistics and Fisher's information, and relates this to different methods suggested by previous authors. Normally distributed, binary, ordinal and survival data are considered. Both the fixed effects and random effects model for treatments are described.