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Methods for dose finding studies in cancer clinical trials: A review and results of a monte carlo study
Author(s) -
O'Quigley John,
Chevret Sylvie
Publication year - 1991
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780101104
Subject(s) - computer science , clinical trial , monte carlo method , scheme (mathematics) , management science , medical physics , econometrics , medicine , statistics , mathematics , mathematical analysis , pathology , economics
We discuss some of the statistical approaches to the design and analysis of phase I clinical trials in cancer. An attempt is made to identify the issues, particular to this type of trial, that should be addressed by an appropriate methodology. A brief review of schemes currently in use is provided together with our views of the extent to which any particular scheme addresses the main issues. Some simulations are provided together with graphical illustration of the operating characteristics of the particular methods. It appears that the continual reassessment method is preferable to other contending schemes.