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Recovery of inter‐block information in cross‐over trials
Author(s) -
Chi Eric M.
Publication year - 1991
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780100711
Subject(s) - block (permutation group theory) , residual , computer science , block design , variance (accounting) , variance components , generalized least squares , statistics , component (thermodynamics) , algorithm , mathematics , estimator , combinatorics , physics , accounting , business , thermodynamics
For cross‐over designs, we show that one can recover information on direct and/or residual treatment effects from an inter‐block (patients as blocks) analysis as is done in an incomplete block design. 1 By combining the intra‐ and inter‐block estimates, we obtain the generalized least squares estimate. In analysing cross‐over trials, we recommended this approach provided the between‐patient variance component can be estimated efficiently.