Recovery of inter‐block information in cross‐over trials | Zendy

Chi Eric M. | Zendy

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Recovery of inter‐block information in cross‐over trials

Author(s) -

Chi Eric M.

Publication year - 1991

Publication title -

statistics in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.996

H-Index - 183

eISSN - 1097-0258

pISSN - 0277-6715

DOI - 10.1002/sim.4780100711

Subject(s) - block (permutation group theory) , residual , computer science , block design , variance (accounting) , variance components , generalized least squares , statistics , component (thermodynamics) , algorithm , mathematics , estimator , combinatorics , physics , accounting , business , thermodynamics

For cross‐over designs, we show that one can recover information on direct and/or residual treatment effects from an inter‐block (patients as blocks) analysis as is done in an incomplete block design. 1 By combining the intra‐ and inter‐block estimates, we obtain the generalized least squares estimate. In analysing cross‐over trials, we recommended this approach provided the between‐patient variance component can be estimated efficiently.

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