Premium
Maximum likelihood techniques applied to method comparison studies
Author(s) -
Nix A. B. J.,
Dunstan F. D. J.
Publication year - 1991
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780100619
Subject(s) - computer science , maximum likelihood , statistics , econometrics , mathematics
One component of method comparison studies is the assessment of relative bias. Most authors use ordinary regression techniques for this purpose. The potential inadequacies in this approach are highlighted and a more generally applicable maximum likelihood technique proposed. The properties of the various methods of estimation are obtained by means of a simulation study, using a variety of different within‐assay precision profiles.