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On the use of historical controls in the analysis of laboratory data
Author(s) -
Yoshimura Isao,
Hayashi Makoto
Publication year - 1991
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780100606
Subject(s) - computer science , significance testing , statistics , multiple comparisons problem , statistical hypothesis testing , econometrics , data mining , mathematics
Our purpose is to propose a method of data analysis incorporating historical controls. It consists of three steps of hypothesis testing procedure. The first step is the check of concurrent controls. The second is the significance testing of treatment groups in comparison with historical controls which are composed of negative and positive controls. The third is the significance testing of a linear trend of the dose‐response relationship. The superiority of the proposed procedure is also verified.