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The construction of biochemical reference ranges and the identification of possible adverse drug reactions in the elderly
Author(s) -
Lawrence C. J.,
Trewin V. F.
Publication year - 1991
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780100605
Subject(s) - identification (biology) , drug reaction , drug , computer science , medicine , pharmacology , biology , botany
In the assessment of adverse drug reactions (ADRs) it is important to establish what is a normal range of values for a given biochemical measurement. Furthermore, such ranges need to be specific to the study population, for example, the elderly. A mixture of Gaussian distributions has been used in the construction of the reference ranges with maximum likelihood used to obtain estimates of the unknown parameters. With this approach, well‐defined reference ranges have been established. Brief details are given of the numbers of ADRs identified in the study population using these ranges.