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Survival analysis techniques in angina pectoris trials
Author(s) -
Bristol D. R.,
Castellana J. V.
Publication year - 1990
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780090312
Subject(s) - angina , medicine , placebo , clinical trial , stress test , stress testing (software) , physical therapy , survival analysis , test (biology) , cardiology , computer science , myocardial infarction , alternative medicine , paleontology , finance , pathology , economics , biology , programming language
Abstract The variable ‘walking time to moderate angina’ on an exercise stress test is the primary means to judge the efficacy of new treatments for angina pectoris. Unfortunately, ‘walking time to moderate angina’; is often censored by fatigue or other reasons for premature termination of the exercise stress test. If time to fatigue is not treatment‐dependent, we propose use of survival analysis techniques in such trials. We present an example from a placebo‐controlled multicentre clinical trial and results of simulations that compare various methods of analysis.