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Efficient use of endpoints in clinical trials: A clinical perspective
Author(s) -
Terrin Michael L.
Publication year - 1990
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780090122
Subject(s) - clinical endpoint , endpoint determination , clinical trial , perspective (graphical) , surrogate endpoint , point (geometry) , medicine , computer science , medical physics , statistics , mathematics , artificial intelligence , geometry
Efficiencies in the use of endpoints in clinical trials are hard won, not easy. They depend upon the shifting of study resources among clinical centres and central units, as well as between numbers of participants and the costs of the endpoint measurement. Costs of endpoint measurement and evaluation do not tell the whole story; nor do costs multiplied by the total number of patients to be recruited; other costs generated by a particular endpoint must also be taken into account. Each clinical trial must be considered separately for the efficient use of endpoints.