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Predicting the range of plasma carbamazepine concentrations in patients with epilepsy
Author(s) -
RacinePoon A.,
Dubois J. P.
Publication year - 1989
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780081105
Subject(s) - carbamazepine , epilepsy , range (aeronautics) , plasma concentration , plasma , medicine , anesthesia , pharmacology , materials science , psychiatry , physics , composite material , quantum mechanics
A statistical model is proposed for predicting the range of plasma carbamazepine concentrations after administration of a controlled‐release formulation at steady state. The model is based on previous clinical studies in patients with epilepsy. The predicted range may be used to monitor and adjust treatment in a patient.