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A method for the evaluation of dose‐toxicity relationships in clinical trials
Author(s) -
Mather Frances J.,
Simon Richard M.,
Clark Gary M.,
Von Hoff Daniel D.
Publication year - 1989
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780080706
Subject(s) - mitoxantrone , toxicity , clinical trial , medicine , oncology , statistics , computer science , mathematics , chemotherapy
This paper considers a proportional hazards model that describes the relationship between time‐dependent cumulative dose of drug and development of toxicity. We estimate probabilities of developing toxicity in both the presence and the absence of competing risks and provide variances for the latter case. Mitoxantrone data collected in Southwest Oncology Group studies illustrate the methods.