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Regression models for time to seroconversion following experimental bovine leukaemia virus infection
Author(s) -
Lassauzet MarieLiesse G.,
Johnson Wesley O.,
Thurmond Mark C.
Publication year - 1989
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780080610
Subject(s) - seroconversion , virology , regression analysis , regression , immunology , statistics , virus , medicine , biology , mathematics
This paper develops a parametric model for time to seroconversion after experimental bovine leukaemia virus (BLV) infection, and examines the effects of inoculation route, volume of inoculum, type of inoculation material, and antigen status of donor on seroconversion time. We used parametric and nonparametric statistical methodology to analyse interval data on 150 animals from 13 published reports. The log‐logistic model fitted the observed times to seroconversion better than the log‐normal or Weibull models, which were the considered alternatives.