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The impact that group sequential tests would have made on ECOG clinical trials
Author(s) -
Rosner Gary L.,
Tsiatis Anastasios A.
Publication year - 1989
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780080413
Subject(s) - clinical trial , clinical endpoint , sequential analysis , group (periodic table) , early stopping , medicine , computer science , oncology , medical physics , statistics , mathematics , artificial intelligence , chemistry , organic chemistry , artificial neural network
Using designs that several authors proposed, we reanalysed a large number of completed phase III clinical trials of the Eastern Cooperative Oncology Group as if each had been designed with group sequential stopping rules. With survival the primary endpoint of the large multicentre trials, we discuss the relative merits of each design, as well as the feasibility of group sequential designs in general.