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Correcting for the bias caused by drop‐outs in hypertension trials
Author(s) -
Murray Gordon D.,
Findlay Janet G.
Publication year - 1988
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780070905
Subject(s) - hypertension treatment , clinical trial , drop out , medicine , blood pressure , mechanism (biology) , essential hypertension , intensive care medicine , economics , philosophy , epistemology , demographic economics
A major source of bias in hypertension trials can arise from patients who are withdrawn during the course of the trial because of inadequate blood pressure control. We develop a mechanism which allows for such withdrawals while preserving the potential to make an unbiased comparison of the treatment effects. The approach is illustrated using data from a large multicentre trial of two anti‐hypertensive agents in patients with mild to moderate essential hypertension.