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The statistical analysis of treatment effects in 24‐hour ambulatory blood pressure recordings
Author(s) -
Marler Matthew R.,
Jacob Rolf G.,
Lehoczky John P.,
Shapiro Alvin P.
Publication year - 1988
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780070608
Subject(s) - ambulatory , statistical analysis , subject (documents) , circadian rhythm , statistics , computer science , statistical model , ambulatory blood pressure , econometrics , medicine , mathematics , library science
This paper presents a statistical analysis of treatment effects in 24‐hour ambulatory blood pressure recordings. The statistical models account for circadian rhythms, subject effects, and the effects of treatment with drugs or relaxation therapy. In view of the heterogeneity of the subjects, we fit a separate linear model to the data of each subject, use robust statistical procedures to estimate the parameters of the linear models, and trim the data on a subject by subject basis. We use a meta‐analytical method to combine the results of all subjects in the study.