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Modified replacement randomization
Author(s) -
Abel U.
Publication year - 1987
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780060205
Subject(s) - randomization , selection (genetic algorithm) , restricted randomization , range (aeronautics) , selection bias , statistics , computer science , clinical trial , mathematics , medicine , artificial intelligence , materials science , composite material
We propose a slight modification of replacement randomization by imposing an imbalance criterion within a restricted range of patient entry numbers. The bound on imbalance is stated most simply in terms of the maximum allowable difference in treatment assignments at the end of the trial. For clinical trials in which two therapies are compared, we study, by means of computer simulations, the dependence of both selection bias and the mean number of randomization list replacements on the parameters defining the procedure.