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Considerations of statistical power in the shared‐haplotypes test
Author(s) -
Ewens W. J.
Publication year - 1986
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780050309
Subject(s) - haplotype , statistical power , test (biology) , statistical hypothesis testing , genetics , power (physics) , human leukocyte antigen , computer science , statistics , gene , biology , mathematics , allele , physics , paleontology , quantum mechanics , antigen
This paper considers statistical power properties of a test of whether a disease is caused by a recessive gene, using data on HLA sharing properties of affected sibs. It is found that the test has very poor power characteristics, and in particular we are sometimes just as likely to accept the hypothesis that the gene is recessive when it is dominant as when it is truly recessive.