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Assessing apparent treatment—covariate interactions in randomized clinical trials
Author(s) -
Byar David P.
Publication year - 1985
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780040304
Subject(s) - covariate , context (archaeology) , randomized controlled trial , clinical trial , econometrics , statistics , computer science , medicine , mathematics , biology , paleontology
In the context of clinical trials, a qualitative treatment—covariate interaction occurs when a patient's preferred treatment depends on his covariates. In this paper I review the nature and interpretation of various kinds of interactions, compare the use of overall tests for interaction to subset analysis, present some examples of apparent treatment‐covariate interactions that have arisen in actual randomized clinical trials, and discuss some recent work by others related to significance testing, estimation and assessment of apparent treatment—covariate interactions.