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Multicentre clinical trials: Bradford Hill's contributions and some subsequent developments
Author(s) -
Fleiss Joseph L.
Publication year - 1982
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780010413
Subject(s) - clinical trial , medicine
Most large comparative trials of therapeutic agents are now conducted as multicentre studies. Some of the major studies designed by Bradford Hill were also multicentre, and his methods of design and conduct remain valid today, even though improved methods for analysing the data have appeared subsequently.