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The effect of unbalanced randomization on the progressively censored savage test
Author(s) -
Lesser Martin L.
Publication year - 1982
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780010309
Subject(s) - randomization , statistics , test (biology) , econometrics , restricted randomization , mathematics , computer science , medicine , randomized controlled trial , biology , paleontology
Abstract Equal allocation of patients to treatment in a randomized clinical trial may have disadvantages ethically if the new treatment is believed to be at least as beneficial as the standard treatment. Others have considered, in a non‐sequential setting, unbalanced randomized designs which allocate fewer patients to the potentially inferior standard treatment. This paper examines unbalanced randomized designs in a sequential comparison of two exponential survival distributions using the progressively censored Savage test. The results reveal no substantial sacrifice in asymptotic power or early stopping properties.