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The detection of adverse reactions to therapeutic drugs
Author(s) -
Finney D. J.
Publication year - 1982
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780010208
Subject(s) - drug reaction , computer science , inference , process (computing) , risk analysis (engineering) , strengths and weaknesses , action (physics) , adverse drug reaction , intensive care medicine , drug , medicine , artificial intelligence , psychology , pharmacology , social psychology , physics , quantum mechanics , operating system
The risk that a drug newly introduced into medical use will occasionally cause adverse reactions is neither negligible nor totally avoidable. Only well organized systems of monitoring can bring early detection and appropriate action. These in turn require either detailed supervision or spontaneous reporting. The paper is concerned with statistical inference from reports spontaneously submitted, and its logical limitations; it discusses strengths and weaknesses of the UK system, the detection process, and automated signalling.